Category

Endocannabinoid System

Endocannabinoid Signaling in Autism

By | Autism, Endocannabinoid System, Research Articles

Endocannabinoid Signaling in AutismIn July 2015, Neurotherapeutics published an article about Autism spectrum disorder (ASD), presenting a modern view of the endocannabinoid (eCB) system, and alterations of its main components in human patients and animal models relevant to ASD. Our understanding of eCB signaling in autism is still in its infancy compared with other disorders of the central nervous system or of peripheral tissues, where eCB-based therapies have already reached preclinical and clinical phases. However, research in this field is rapidly evolving, and novel drugs able to hit specifically a distinct element of the eCB system are being developed at a surprising speed. Read More

Osteoarthritis Pain And Cannabinoids

By | Arthritis, Chronic Pain, Endocannabinoid System, Pain, Research Articles
Osteorthritis Pain And CannabinoidsOsteoarthritis and cannabis – Information comes from scientists in the UK and USA, published in PLOS ONE in 2013. Osteoarthritis pain is challenging to treat, with chronic pain leading to central sensitization. Cannabinoids can help. This data provides new clinically relevant evidence that joint damage and spinal CB2 receptor expression are correlated combined with converging pre-clinical evidence that activation of CB2 receptors inhibits central sensitization and its contribution to the manifestation of chronic OA pain. These findings suggest that targeting CB2 receptors may have therapeutic potential for treating OA pain.

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Anandamide Inhibits Breast Tumor-Induced Angiogenesis

By | Anandamide, Breast Cancer, Cancer, Endocannabinoid System, Research Articles

Anandamide Inhibits Breast Tumor-Induced AngiogenesisEndocannabinoid Anandamide and Breast Cancer – more evidence. This 2014 study out of Italy, published in the journal Translational Medicine, found that following anandamide treatment, MDA-MB-231 cells lose their ability to stimulate endothelial cells proliferation in vitro, due to a significant inhibition of all the pro-angiogenic factors produced by these cells. This finding adds another piece of evidence to the anti-tumor efficacy of anandamide in breast cancer. Read More

Human Cannabinoid Receptor Gene Associated With Happiness

By | Endocannabinoid System, Mental Health, Research Articles

Human Cannabinoid Receptor Gene Associated With Happiness | Cannabis and Mood

This 2014 study out of Japan indicated that genetic traits, specifically the CB1 receptor gene genotypes, are closely related to happiness. C allele carriers of the SNP of CNR1 who are sensitive to positive emotional stimuli may experience a higher magnitude pleasure response when they experience positive events and may have a higher subjective happiness level. Read More

THC & Exercise Performance

By | Endocannabinoid System, Research Articles, THC

THC And Exercise Performance | THC Research

In a 2013 issue of the journal Nutrition & Metabolism, four drugs (ethanol, caffeine, nicotine & THC) were evaluated for their effect on exercise metabolism. Overall, it appears that cannabis does not have ergogenic potential in sports activities and thus, its inclusion on the banned list is likely a function of its illicitness. Read More

Cannabinoid Receptor Pharmacology

By | CBD, Endocannabinoid System, Research Articles, THC, THCV

Cannabinoid Receptor Pharmacology | Cannabinoid Receptor Agonists

Cannabis sativa is the source of a unique set of compounds known collectively as plant cannabinoids or phytocannabinoids. This review published in 2008 in the Journal of British Pharmacology focuses on the manner with which three of these compounds, (_)-trans-D9-tetrahydrocannabinol (D9-THC), (_)-cannabidiol (CBD) and (_)-trans-D9-tetrahydrocannabivarin (D9-THCV), interact with cannabinoid receptors CB1 and CB2. Read More